Granisetron transdermal system: a new option to help prevent chemotherapy-induced nausea and vomiting.

نویسنده

  • Lisa Schulmeister
چکیده

Transdermal medication delivery systems provide systemic therapy by passive diffusion through the skin. They offer an alternative route of medication administration and may be well suited for patients who are unable to take or retain oral medications. Granisetron transdermal system (Sancuso(R), ProStrakan, Inc.) is the first transdermal medication patch indicated for the prevention of nausea and vomiting in patients receiving moderately or highly emetogenic chemotherapy. As with all transdermal medications, safety considerations exist with respect to storing, handling, applying, and disposing of the granisetron transdermal system. Oncology nurses should be aware of new developments in the management of chemotherapy-induced nausea and vomiting and knowledgeable about transdermal medication delivery.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review

Until now only intravenous and oral formulations of 5HT(3) receptor antagonists have been available. Recently a new formulation of a 5HT(3) receptor antagonist, transdermal granisetron, has been developed, and approved by the FDA. Three phase I studies to evaluate its pharmacokinetic profile have shown that granisetron administered by a transdermal delivery system is absorbed by passive diffusi...

متن کامل

Use of transdermal and intravenous granisetron and the ability of the Hesketh score to assess nausea and vomiting induced by multiday chemotherapy

PURPOSE Hesketh scores define emetogenicity of single-agent and multiagent single-day chemotherapy. This analysis determined the emetogenicity of multiagent, multiday chemotherapy and the Granisetron Transdermal System (GTDS; Sancuso(®)). METHODS This was a retrospective analysis of a multicenter, randomized, double-blind, phase III noninferiority trial of GTDS versus oral granisetron in pati...

متن کامل

Enhanced Transdermal Delivery of Granisetron by Using Iontophoresis

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...

متن کامل

Enhanced Transdermal Delivery of Granisetron by Using Iontophoresis

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...

متن کامل

Granisetron Transdermal System for Treatment of Symptoms of Gastroparesis: A Prescription Registry Study

Background/Aims Serotonin receptor (eg, 5-HT₃) antagonists are used to treat nausea and vomiting from a variety of causes. Granisetron transdermal system (GTS) is an appealing delivery system for patients with gastroparesis. To assess if GTS improves nausea and vomiting and other gastroparesis symptoms in patients with gastroparesis. Methods Patients with gastroparesis and symptoms of nausea ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical journal of oncology nursing

دوره 13 6  شماره 

صفحات  -

تاریخ انتشار 2009